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These contrasting results observed with
2020-06-05
These contrasting results observed with intra-BNST combined injections of NOC-9 and CP 376395 on freezing (in the novel arena) versus anxiety-related behavior (in the EPM) suggest that CRF neurotransmission within this forebrain limbic site could be mainly involved in the modulation of more subtle a
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Introduction The carnitine choline acyltransferase family is
2020-06-05
Introduction The carnitine/choline acyltransferase family is a family of enzymes that play diverse roles, ranging from (the regulation of) 221 2 and fuel metabolism in mitochondria and peroxisomes to the generation of the neurotransmitter acetylcholine. In mammals, this family consists of seven tr
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Results from H also complement work of the AICPA
2020-06-05
Results from H5 also complement work of the AICPA Board of Examiners, which has concluded “newly licensed CPAs must demonstrate higher-order skills such as critical thinking, problem solving, analytical ability, and skepticism more frequently. It is critically important that newly licensed CPAs are
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The CPA parameters of SO
2020-06-05
The CPA parameters of SO2 were calculated based on Eq. (11) using the vapor pressure and saturated liquid density data of SO2 over the reduced temperature range of 0.55 to 0.9. All of the data used were taken from the NIST database [53]. The resulting CPA parameters of SO2 are presented in Table S1
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Higher versus lower order skills can also
2020-06-05
Higher versus lower order skills can also be understood in the context of the CPA exam. The CPA exam tests four broad topics (FAR, AUD, BEC, REG) using three different testing modes: multiple-choice, task-based simulations and written communications. Combined, the three testing modes place more emph
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The collagen field undoubtedly regains attractiveness with t
2020-06-05
The collagen field undoubtedly regains attractiveness with the emergence of new concepts (cell niche, regulation of growth factor bioavailability, mechanotransduction, cell microenvironment sensing) and new tools to investigate their in vivo functions (atomic force microscopy (AFM), second harmonic
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VO-Ohpic trihydrate br Disclosure and conflicts of interest
2020-06-05
Disclosure and conflicts of interest Acknowledgements This research was supported by grant (BT/PR/11293/BRB/10/849/2008) from Department of Biotechnology (DBT), Government of India and a DST YOS Chair Professorship to PB. The mass spectrometry facility is supported by an institutional program
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The repeat sequence TTAGGG of telomere could be directly rec
2020-06-04
The repeat sequence “TTAGGG” of telomere could be directly recognized by TERF1. TERF1 is indispensable for the maintenance of telomere bromocriptine mesylate structure and integrity (Tan et al., 2017). Trf1 genetic depletion in vivo induces a persistent DNA damage response and telomere uncapping, w
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Although several genomic technologies including the generati
2020-06-04
Although several genomic technologies, including the generation of ERRγ-specific knockout mice, have revealed that ERRγ plays a pivotal role in cellular bioenergetics [1], its involvement in other metabolic pathways has been appreciated only recently. Therefore, we highlight recent findings on the r
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br Introduction Maintaining the normal function of
2020-06-04
Introduction Maintaining the normal function of fetal trophoblasts is essential for a successful pregnancy. Preeclampsia (PE), a pregnancy-specific disorder, is often associated with excessive trophoblast cell apoptosis and superficial trophoblast invasion leading to insufficient spiral artery re
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It has been reported that the ECD of DDRs
2020-06-04
It has been reported that the ECD of DDRs require dimerization and/or oligomerization for binding to collagen.,, Here, we have established using SPR that antibody-mediated oligomerization of DDR2-Fc significantly enhances its binding to immobilized collagen type 1. Our results are consistent with ea
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SIRT is a representative member of Sirtuins which is a
2020-06-04
SIRT1 is a representative member of Sirtuins, which is a family of highly conserved NAD+-dependent class III histone deacetylases. SIRT1 deacetylates plentiful nonhistone protein substrates [Atgs, Foxo1, Foxo3, PGC-1α, NF-kB, E2F1 and p53] (Conrad et al., 2016; Gu et al., 2016; Tu et al., 2018) to p
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Since the initial identification of DNA ligase inhibitors by
2020-06-04
Since the initial identification of DNA ligase inhibitors by a structure-based approach [[18], [26]], there have been several reports describing LigI inhibitors using computer modelling and derivatives of the original DNA ligase inhibitors [[49], [50], [51]]. While these studies have shown that the
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Studies of Jelski and Szmitkowski
2020-06-04
Studies of Jelski and Szmitkowski show that differences of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity between hiv protease inhibitors of many cancers and healthy tissue may be one of the factors intensifying carcinogenesis [7]. Moreover, changes of ADH and ALDH activity
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In order to further evaluate cpt a function we determined
2020-06-04
In order to further evaluate cpt1a function, we determined its tissue distribution in large yellow croaker. The mRNA levels of cpt1a were detected in all the tested tissues, but at varying levels. cpt1a mRNA expression was the highest in liver among different tissues, similar to reports in other fis
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