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To confirm that the correlation between CK activity
2020-07-31
To confirm that the correlation between CK2 activity and HSP27 expression is a general phenomenon rather than cell-specific, HEK293T cisapride (human embryonic kidney cell line) and two different tumour cell lines, HeLa (human cervical cancer cells) and HepG2 (human hepatocyte carcinoma cell line),
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Some E s have been shown to bind to
2020-07-30
Some E2s have been shown to bind to co-factors that can alter the activity or subcellular localization of the recruited E2 [28]. One example is the CUE1 co-factor which recruits the cytoplasmic UBC7 (UBE2G2) E2 enzyme to the endoplasmic reticulum (ER) where it participates in the degradation of misf
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Biochemical and genetic evidence supports a central
2020-07-30
Biochemical and genetic evidence supports a central role for the two Nck adapters in cell migration [5]. The generation of knockout mice revealed that Nck1 and Nck2 have largely redundant functions as neither of the single knockouts resulted in a phenotypic alteration, while the Nck1/Nck2 double kno
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EGTA The present study provides the first evidence that the
2020-07-30
The present study provides the first evidence that the human uroepithelial EGTA in vitro respond directly, within 48h, to this carcinogen by promoting extensive vacuolation and DAPK expression. By using the TEM, ICC and Western blotting, we found that the arsenite-induced vacuoles were derived from
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br Conflict of interest br Author contributions
2020-07-30
Conflict of interest Author contributions Acknowledgements This work was supported by Consejo Nacional de Ciencia y Tecnología (grant number CB 220661); Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica (grant numbers IN215316 and IA204817); Programa de Apoyo a Investi
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br Acknowledgments This work was supported
2020-07-30
Acknowledgments This work was supported in part by the Japan Society for the Promotion of Science (JSPS) Grants-in-Aid for Scientific Research, KAKENHI; the Funding Program for Next Generation World-Leading Researchers, Grant No. LS081 (H.H.); Research Fellowships for Young Scientists (Y.O. and R
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Najafloo et al applied eSAFT HR EoS to correlate the
2020-07-30
Najafloo et al. [4] applied eSAFT-HR EoS to correlate the CO2 solubility in MDEA aqueous solutions in various conditions. In this work, 413 VLE data from different authors were utilized to model H2O + MDEA + CO2 system so that the overall overage absolute deviation (AAD) achieved was equal to 11.2.
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The binary interaction parameters were then estimated for al
2020-07-30
The binary interaction parameters were then estimated for all the binary systems involved in the ternary or quaternary systems. References for experimental data, the values of fitted and the average absolute relative deviation (AARD) are shown in Table 3. Mainly for the cosolvent – solute systems a
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br Disclosure of interest br Introduction Among fossil fuels
2020-07-30
Disclosure of interest Introduction Among fossil fuels, natural gas is the cleanest, in terms of CO2 emission, burn efficiency and amount of air pollutant [1]. Methane is the prevailing element of natural gas; therefore, it contains other volatile molecules and a variety of impurities. In fact
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There are few studies targeting
2020-07-29
There are few studies targeting cocaine and corticotropin-releasing factor CRF2 receptor. Boyson and co-workers (Boyson et al., 2014) found that administration of Astressin2-B directly into the ventral tegmental area 20 min before social defeat reversed the escalation and sensitization to dopamine r
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We also found that D dopamine receptor
2020-07-28
We also found that D4 dopamine receptor was significantly up-regulated in hippocampus and striatum and down-regulated in the PFC. The receptor is found in especially KPT-330 receptor areas that are involved in reward and reinforcement such as striatum (Rivera et al., 2002), cerebral cortex, and hip
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Initially the doxorubicin fluorescence assay demonstrated
2020-07-28
Initially, the doxorubicin fluorescence assay demonstrated that NU7441 induces doxorubicin accumulation in a concentration-dependent manner in paired wild-type and MDR1-overexpressing MDCKII cells. The kinase inhibitor sorafenib is used to treat advanced renal cell carcinoma [33] and hepatocellular
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br Dihydroorotate dehydrogenase DHODH catalyzes the conversi
2020-07-28
Dihydroorotate dehydrogenase (DHODH) catalyzes the conversion of dihydroorotate to orotate, which might be the rate-limiting step in the pyrimidine biosynthesis. Inhibitors of DHODH show immunosuppressant and antiproliferative activity, which is most pronounced on T-cells. Two examples of inhibito
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L 006235 br Results br Discussion Our discovery of HPV and m
2020-07-28
Results Discussion Our discovery of HPV16 and 18 methylation and their change during cervical carcinogenesis (Kalantari et al., 2004, Badal et al., 2004, Turan et al., 2006) have become generally confirmed and led to a major expansion of the available data L 006235 (Brandsma et al., 2009, Fer
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The X ray crystal structure of ribociclib bound to CDK
2020-07-28
The X-ray crystal structure of ribociclib bound to CDK6 shows that the N3 of the pyridine fragment hydrogen bonds with the NH group of V101 (the third hinge residue) and the adjacent amino group NH hydrogen bonds with the V101 carbonyl group (Fig. 7C). The drug carbonyl oxygen hydrogen bonds with th
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