• How changes in APP processing by secretase lead to

  2021-11-24

  

  How changes in APP processing by γ-secretase lead to AD is still not well understood. Deposition of amyloid beta (Aβ) peptide fragments of the amyloid precursor protein (APP) in amyloid plaques and hyperphosphorylated tau in neurofibrillary tangles are the cellular hallmarks of AD (O’Brien and Wong,

• While IN inhibitors are a relatively

  2021-11-24

  

  While IN inhibitors are a relatively new addition to the clinician's palette of drugs to formulate HAART regimes, resistance to both INSTIs and LEDGINs has been observed. For example, even within Australia where it is estimated that 25,313 people are currently living with HIV and the infection rate

• The root of Danshen has been widely

  2021-11-24

  

  The root of (Danshen) has been widely used as traditional Chinese medicine for many years and shown to exhibit significant pharmacological activities for a variety of human diseases including cancers. Tanshinones, the major active components, belong to a group of an abietane-type diterpenes containi

• Genistein sale As previously discussed even though

  2021-11-23

  

  As previously discussed, even though glucose is the major fuel of the brain, neuronal cells may use alternative fuels such as ketone bodies in metabolically challenging situations in which glucose availability is limited [6]. Ketogenesis takes place mainly in the liver, although astrocytes can also

• Results from the current study are not consistent

  2021-11-23

  

  Results from the current study are not consistent with those of a previous study (Poock et al., 2015) where there was no differences in ovulation induction response when there was administration of gonadorelin hydrochloride and gonadorelin diacetate salts. These differences in results are likely due

• br Conclusion br Acknowledgments br Introduction Throughout

  2021-11-23

  

  Conclusion Acknowledgments Introduction Throughout history, there is literature that supports the notion that animals can be perceived as “healing”. Overall, there is an increased interest in the general field of Animal Assisted Therapy (AAT). Though the field of equine-facilitated psychoth

• lp-pla2 inhibitor L Family Leguminosae widely distributed in

  2021-11-23

  

  L. (Family Leguminosae) widely distributed in tropical and subtropical regions of the world. As a medicinal and edible plant, it is widely used in Asia, especially in China, Korea, Japan and India. It was first recorded in Shen Nong Ben Cao Jing (神农本草经), and was described having the effect of cleari

• br Methods br Results and discussion br Conclusions A

  2021-11-23

  

  Methods Results and discussion Conclusions A third example of a hexokinase using polyphosphate exclusively as a phosphoryl donor has been identified, this time in mammalian tissues. This is the first polyphosphate utilizing enzyme activity demonstrated in mammalian neuron specific enolase

• Regulation of pancreatic and cell mass has been extensively

  2021-11-23

  

  Regulation of pancreatic α and β cell mass has been extensively studied and hotly debated, due to potential therapeutic implications. Early claims of Angptl8 as “betatrophin” and Angptl4 as a regulator of glucagon secretion and α cell proliferation (Yi et al., 2013, Ben-Zvi et al., 2015) have not st

• The widespread involvement of HH GLI in human

  2021-11-23

  

  The widespread involvement of HH/GLI in human malignancies has initiated a remarkable effort to identify selective HPIs. As shown in Table 2.1, most of these small molecule inhibitors target the essential effector protein SMO, which should lead to pathway abrogation by eventually decreasing the GLIA

• In summary our findings provide the evidence

  2021-11-23

  

  In summary, our findings provide the evidence and the mechanistic understanding of the protective effects of GIP receptor agonist, D-Ala2GIP, in the MPTP-induced neurotoxicity in mice. The observed protective effects are potentially due to reduced oxidative stress and attenuation of dopamine loss in

• br Materials and methods br Results

  2021-11-22

  

  Materials and methods Results Discussion Since early times, herbs and their extracted substances have been used as foods and medicinal resources worldwide (Petrovska, 2012). A Ginger is one of the most important and oldest spices, consisting of the prepared and sun-dried rhizomes of Zingibe

• Accumulating evidence suggests that the NGF family of neurot

  2021-11-22

  

  Accumulating evidence suggests that the NGF family of neurotrophins have important modulatory roles in opioid analgesia and addiction [36]. The NGF family of neurotrophins include NGF, Bacitracin australia derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4) [37]. BDNF

• Mammals adapt to prolonged periods of food scarcity by relea

  2021-11-22

  

  Mammals adapt to prolonged periods of food scarcity by releasing FFAs from adipose tissue and transforming them into energy-rich ketone bodies that are used as fuel by brain, muscle, and other organs (Kersten, 2014, Grabacka et al., 2016). Ketogenesis occurs primarily in hepatocytes, but its rate is

• br Author contributions br Declaration of conflict of intere

  2021-11-22

  

  Author contributions Declaration of conflict of interest Acknowledgements We are grateful to the Director, National Institute of Immunology for his support. The work was partially supported by J.C. Bose Fellowship to SSM. We acknowledge the help from staff of Small Animal Facility of Nation

14334 records 522/956 page Previous Next First page 上5页 521522523524525 下5页 Last page