• The cytoplasmic domain of muscle AChR is not accessible to

  2025-01-14

  

  The cytoplasmic domain of muscle AChR is not accessible to protease inhibitor cocktail in vivo. Theoretically, therapy with the cytoplasmic domains should be safe. Safety is demonstrated by the facts that: (1) rats repeatedly immunized with the cytoplasmic domains in TiterMax adjuvant do not develop

• proteinase k function Molecular docking is widely used to pr

  2025-01-14

  

  Molecular docking is widely used to predict the interaction between an enzyme and its inhibitors. This is a computational simulation approach that can be used as a tool to investigate the structure-activity relationship of ACE inhibitory peptides (Goodsell, 2009). It has been recently shown that ACE

• AXL is a member of the

  2025-01-14

  

  AXL is a member of the TAM (Tyro3, Axl, Mer) family of receptor tyrosine kinases (RTKs) [4]. Elevated AXL expression could promote oncogenic processes such as cell growth, migration, invasion, and epithelial-to-mesenchymal transition (EMT), which substantially contribute to tumor progression and poo

• Our current knowledge on autophagy broadly differentiates

  2025-01-14

  

  Our current knowledge on autophagy broadly differentiates it into three types: macroautophagy, microautophagy, and chaperone-mediated autophagy. Macroautophagy mainly involves the sequestration of cytoplasmic contents in a double-walled membrane followed by the fusion with the lysosomes. The lysosom

• In this study we observed the ATPase activity

  2025-01-14

  

  In this study, we observed the ATPase activity of RaGroEL at various temperatures and metal ions conditions and the role of GroES in the ATPase activity of RaGroEL. Furthermore, we quantified the expression of groEL genes under different abiotic stresses, including temperature, pH, salt and oxygen s

• br Materials and methods br Results In order

  2025-01-14

  

  Materials and methods Results In order to evaluate changes in the amount of PKC-θ expressed by MEL cells at different stages of the cell cycle, we measured the level of the kinase in cells collected from cultures containing 90% of cells in the interphase or 80% cells synchronized at the metaph

• br Material and methods br Results br Discussion RSV is

  2025-01-13

  

  Material and methods Results Discussion RSV is a major cause of lower respiratory tract infections in infancy and early childhood. Several observations suggest that immunological mechanisms may be the key to understand the severity of RSV bronchiolitis in infancy. Several laboratories have

• AAT enzyme activity was readily detected

  2025-01-13

  

  AAT enzyme activity was readily detected in crude cell-free extracts obtained from berry tissues of all accessions but displayed different substrate selectivities (Fig. 2). Cell-free extracts derived from ‘Muscat Hamburg’ berries showed the highest AAT activity with all alcoholic substrates tested,

• pde-5 inhibitors br KYN Acts on AhR To Induce Tolerogenic Im

  2025-01-13

  

  KYN Acts on AhR To Induce Tolerogenic Immunity IDO1 and TDO2 are intracellular heme-containing metalloproteins that catalyze the committing and rate-limiting step of the KYN pathway (KP) that converts the essential amino pde-5 inhibitors tryptophan to a series of biologically active second metab

• The pathogenesis of d penicillamine induced MG

  2025-01-13

  

  The pathogenesis of d-penicillamine-induced MG is not clear. The repertoire of anti-AChR Trigonelline in d-penicillamine-induced MG has been shown to be similar to that in idiopathic MG in terms of AChR antigenic regions, suggesting a common immune mechanism (Tzartos et al., 1988). About 20% of d-

• The biological characteristics of cancer invasion

  2025-01-13

  

  The biological characteristics of cancer invasion and metastasis are mainly attributed to the poor prognosis in cancer. It has been reported that overexpression of Ack1 promoted the migratory and invasive properties of breast cancer BI-9564 by sustaining expression of epidermal growth factor. In co

• In this report the natural compound deguelin potently and

  2025-01-13

  

  In this report, the natural compound deguelin potently and dose-dependently suppressed Aurora B kinase activity in vitro, indicating that this compound is an effective Aurora B inhibitor. The docking study indicated that deguelin was docked into the ATP-binding pocket of Aurora B and formed hydropho

• According to the present observations the Ampk

  2025-01-10

  

  According to the present observations, the Ampkα1 isoform promotes AP-1 transcriptional activity and thereby fosters Amrubicin synthesis of AP-1 target genes in cardiomyocytes via activation of Pkcζ. The transcription factor AP-1 plays a decisive role during cardiac remodeling [24], [25], [26], [37]

• Interestingly metabolic dysfunction is also observed

  2025-01-10

  

  Interestingly, metabolic dysfunction is also observed in amyotrophic lateral sclerosis (ALS). Patients and mouse models of familial ALS exhibit higher levels of resting Natural flavonoid expenditure and lower fat-free mass, indicating a hypermetabolic phenotype. Lim et al. (2012) found that reducing

• br Aldehyde sensors to monitor substrate levels Previous eff

  2025-01-10

  

  Aldehyde sensors to monitor substrate levels Previous efforts to ameliorate metabolic diseases frequently relied on biochemical methods which could measure the levels of toxic substrates in Cystic fibrosis treatment or bodily fluids (blood and serum or plasma, urine, cerebrospinal fluid). Therap

14232 records 23/949 page Previous Next First page 上5页 2122232425 下5页 Last page